Mechanics of Epithelial Tissues: Structure, Rigidity and Fluidity
报告人： Dapeng “Max” Bi博士，美国东北大学物理系助理教授
Assistant Professor, Department of Physics
Northeastern University, Boston, Massachusetts, USA
Cells must move through tissues in many important biological processes, including embryonic development, cancer metastasis, and wound healing. Often these tissues are dense and a cell's motion is strongly constrained by its neighbors, leading to glassy dynamics. Although there is a density-driven glass transition in particle-based models for active matter, these cannot explain liquid-to-solid transitions in confluent tissues, where there are no gaps between cells and the packing fraction remains fixed and equal to unity. I will demonstrate the existence of a new type of rigidity transition that occurs in confluent tissue monolayers at constant density. The onset of rigidity is governed by a model parameter that encodes single-cell properties such as cell-cell adhesion and cortical tension. I will also introduce a new model that simultaneously captures polarized cell motility and multicellular interactions in a confluent tissue and identify a glassy transition line that originates at the critical point of the rigidity transition. This work suggests an experimentally accessible structural order parameter that specifies the entire transition surface separating fluid tissues and solid tissues.
个人简介：Dapeng “Max” Bi博士本科毕业于Binghamton大学物理系，于2012年Brandeis大学物理学博士学位。之后先后在Syracuse大学及Rockefeller大学从事研究工作，现为美国东北大学物理系助理教授。长期从事软物质物理及生物物理研究，在颗粒材料的统计物理及生物组织的力学行为领域取得了重要的研究成果，在Nature、Nature Materials、Nature Physics、Physical Review Letters等顶级学术杂志上发表了多篇文章。